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Synecta™ T1 CDNP
Synecta T1 is made for easy and robust T cell activation and expansion
Composition
Activation signal and co-stimulatory ligands:
OKT3 scFV, CD86, 4-1BBL
Cytokines:
IL-15RA/IL-15, IL-7
- Transduce on Day 0
- Activate without addition of soluble cytokines
- Use any serum-free or serum-containing medium
- Easily adaptable protocols for use with a variety of vessels (e.g., flasks) and bioreactors (e.g., Grex®)
- Finalize drug product formulation without a de-beading step
- Maximize cell yield while avoiding overstimulation by adjusting dose
- Activate PBMC, or either negatively or positively selected T cells
Synecta™ T1 Simplifies Manufacturing
- Improved cell yields at any time from Day-3 onward without adding soluble cytokines
- Success with hard-to-expand cells
T cell phenotypes similar to widely used activators, while promoting favorable traits such as sustained CD62L⁺ expression
Synecta T1 induces increasing percentages of CD62L+ T cells
- Equal or better Day 0™ lentiviral transduction efficiency vs. Day 1 transduction with comparators
- High cell viability
- CD4/CD8 ratios consistent with widely used activators
- Improved CAR-T proliferation in vitro and tumor control in vivo
- Less labor, material, and capital costs
Savings with Synecta T1 Accumulate to $100s of Millions Over the Product Life
Synecta T1 is easy to use, with high dose-dependent cell yields, and a recommended dose of 30 μL of Synecta T1 per 1 million cells. The product is agnostic to the media used in manufacturing, cell isolation techniques, and bioreactors. We strongly recommend adding lentivirus vectors on Day 0 together with Synecta T1.
Synecta T1 is stored at -80°C long term. Once thawed the product can be refrozen once.
Synecta T1 CDNPs are provided in a crystal AT-Closed Vial® for improved sterility. A vial adapter or syringe can be used to apply or aliquot the product.
Protocol
Frequently Asked Questions (FAQ)
Certificate of Analysis (CoA), Safety Data Sheet (SDS)
Example CoA
Safety Data Sheet (SDS)